Endocrine Abstracts

A 47-year-old female presented to the Emergency department following an episode of loss of consciousness at home that her daughter had identified as due to hypoglycaemia (using her husband’s capillary blood glucose meter 1.1mmol/l) and treated. She reported several episodes of fainting, sweating and generalised weakness over 6 months which improved after eating snacks. There was no previous history of diabetes; she had been diagnosed with Graves’ disease 6 months pre...

Background: Over the past decade there has been increased recognition of the dangers associated with inpatient management of diabetes insipidus (DI) and omission of desmopressin leading to hypernatremia. In May 2009 a patient died from diabetes insipidus mismanagement in a London hospital. An NHS England patient safety alert was issued in 2016 highlighting this risk.Method: Inpatients with a serum sodium of 155 mmol/l or greater were prospectively identi...

Congenital isolated hypogonadotropic hypogonadism (CHH), is a condition characterized by a defect in development, migration and action of GnRH neurons. Numerous genes are involved in CHH. It can present with anosmia, hyposmia or normosmia. Two cases presented to our department with late onset delayed puberty. First case was a 29 year old with absence of secondary sexual characters along with micropenis and anosmia. His younger brother, 22 year old had similar complain...

Sertoli-Leydig cell tumours are rare comprising 0.2–1.2% of all primary ovarian cancers. Virilisation is seen in 30–50% of cases. Heterologous Sertoli-Leydig cell tumours with dominant cystic component are even rarer and mainly affect females aged 20 to 30 years. A 66-year-old lady was referred to the Endocrine Department with a one year history of rapid severe hirsutism involving the limbs, abdomen, chest, face and thinning of hair on the scalp. Blood pressure of 15...

Cushing’s syndrome (CS) is a rare endocrine problem in children. Most of the cases in children are iatrogenic in nature due to extensive usage of topical, inhaled and oral corticosteroids. Endogenous hypercortisolism in children is mainly because of ACTH-dependent pituitary adenomas and constitutes ~70–80% of CS in children. ACTH-independent CS is rare in children above 5 years of age. Here, we are presenting a rare case of ACTH-independent macronodular adrenal hyper...

Case: A 25-year-old lady was incidentally found to have hyponatremia while she was investigated for painful left ankle and hand swelling. At the time of review in endocrine clinic, she was completely asymptomatic. Her menstrual period was normal. On examination she was found to be hypertensive with consistent blood pressure of 188/110. Rest of the systemic examination was unremarkable. Investigations revealed biochemical findings consistent wi...

A 25 year old lady was referred to the endocrine clinic after her newborn baby was noted to have respiratory problems, marked osteopenia and hypocalcemia. Further investigations on the mother showed corrected calcium of 1.11 mmol/L; however she was relatively asymptomatic. Reviewing her history in detail, she was born in Nigeria and moved to the UK 2 years prior to the presentation. She used to get intermittent cramps in her hands, legs and body since the age of 10 in addition...

Background: Adrenal incidental masses (incidentalomas) are present in up to 10% of patients. The majority of these adrenal masses are clinically inapparent, but may be functionally active in a significant proportion; thus assessment by endocrinologists is essential.We assessed the functionality of adrenal incidentalomas referred to the endocrinology team at the Queen Elizabeth Hospital in Gateshead.Methods: Patients with adrenal in...

Forty two year Mrs SJ, community support worker with a background history of hypothyroidism was referred by her GP with excessive tiredness and weight gain. She had been attending her surgery for few months with somatic symptoms and her GP had noticed significant change in facial characteristics and large hands. She complained of increase in her feet size from a size 6 to a 9. No disturbance of vision was reported.She was noted to have hyperglycaemia and...

Gitelman’s syndrome (GS) is a rare autosomal recessive renal tubular disorder caused by defects of thiazide sensitive Na-Cl co-transporter due to mutations of the SLC12A3 gene.We report a case of a 23-year-old woman, who presented with excessive tiredness in her second pregnancy. She had a past history of hypokalaemia in a previous pregnancy (attributed to ‘vomiting’), which required multiple admissions for i.v. potassium replacement despi...